Pigmentation Abnormalities

Patients with vitiligo have low catalase levels in their epidermis in association with high levels of hydrogen peroxide. Topical application of a UVB-activated pseudocatalase cream can successfully remove epidermal H2O2 resulting in a remarkable repigmentation.

J Investig Dermatol Symp Proc 1999 Sep;4(1):91-6
In vivo and in vitro evidence for hydrogen peroxide (H₂O₂)accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase.

Schallreuter KU, Moore J, Wood JM, Beazley WD, Gaze DC, Tobin DJ, Marshall HS, Panske A, Panzig E, Hibberts NA.
Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK.

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